Hi,
TL;DR - yes.
There are multiple datasources supported. Prometheus-compatible (that I know of) are Grafana Mimir and VictoriaMetrics (although I think both are added as Prometheus.
Aside from those, you have options for multiple tools, you can view them by going into Connections → Data sources → Add datasource (there’s a list, sample of in screen below):
there’re also multiple plugins you can install for your instance (some of them in Enterprise / Cloud version only). There are datasources that fetch data from Rest API (e.g. Infinity Plugin), that connect to databases (Postgres, Mongo) or for logs (Elasticsearch / Loki).
This really depends on what you want.