Very large site using grafama with prometheus - configuration help requested

Hello all
Please excuse a newbie inquiry that might be addressed elsewhere - if so I cannot find it!

I have a site with an very large number of hosts (images), more than 5,000. Each of these are Linux “servers” and each has multiple Linux “clients”. Each “server” runs prometheus but the “clients” only run “exporters”. All the data goes back up to Grafana. The describes it. OK, so what is the best way, or at least a very good way, to configure / organize this site? All IP addresses are static and we do not run “Discovery”. Greatly appreciate any feed back or links to where I can get details on an efficient way to build out this system.