I have noted an unexepected (To me) behaviour which is easily replicated (On my instance anyway)
I have a graph panel plotting several series and using a second y-axis. If I apply or change the “Alias By” field when editing the panel, the Y-Axis preference is set to default Y-Axis… It can be reset afterwards.
In the above panel - after changing the Alias of Humidity, the editor reset the Axis to plot against temperature in the left panel.
As I say there is an easy workaround, but the behaviour seems unexpected to me.